Response of single medial geniculate units to repetitive click stimuli.
نویسندگان
چکیده
VERNIER, VERNON G. AND ROBERT GALAMBOS. (Walter Reed Army Med. Ctr., Washington, D. C.) Response of single medial geniculate units to repetitive click stimuli. Am. J. Physiol. 188(2): 233-237. Io57.-The capacity of single units isolated in the medial geniculate of unanesthetized, paralyzed cats to respond to clicks delivered to the ear at rates between I and 2oo/sec. is described. Most units respond one-to-one at low click rates. When the interval between stimuli is shortened some stimuli fail to evoke response, and when it is made very brief the unit may respond only to the first click in the train. The click frequency at which a unit responds to 50% of the stimuli is reasonably stable, but can be modified by the administration of morphine. T HE TWO IDEAS behind the studies reported here were first to add to the available (I, 2) information upon the behavior of single medial geniculate units, and second, to discover what if any changes in that behavior occur when active pharmacological agents are introduced into the blood stream of the animal. To these ends the capacity of the units to respond to clicks presented at low, intermediate and high rates was determined. As will be developed, the units fail to follow successive stimuli at certain critical rapid rates in the normal animal, and this point of failure may be significantly altered by pharmacological agents. It is well known that a need for quantitative methods for the assay of the effects of drugs upon the nervous system exists, and our success in using single units for this purpose, while limited, may be of interest.
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عنوان ژورنال:
- The American journal of physiology
دوره 188 2 شماره
صفحات -
تاریخ انتشار 1957